21. Peyton Manning (2012)
Manning suffered horrible injuries in his final seasons with the Colts. He sat out for 2011 with injuries and watched the franchise flop to a 2-14 record. It was appalling but it left the franchise in an interesting position. They were now in possession of the No. 1 draft pick and had their eyes on Andrew Luck. But this meant that it was the end of Manning’s run as starting quarterback.

They duly released their legendary signal-caller after 13 seasons because they didn’t trust his body (via USA TODAY). Manning went to Denver where he made two Super Bowl appearances and won one. Luck played very well for the Colts but ironically retired in his prime because his body broke down. However, he was a four-time Pro Bowler so it would be wrong to say it didn’t work out.