10. Daunte Culpepper (2005)
The Minnesota Vikings drafted Culpepper in 1999. However, it wasn’t until 2004 that he enjoyed his breakout season in the NFL. This was the best year of his Vikings tenure but his career came to a cruel end. Culpepper broke the record for total yardage by a quarterback. He also led the league in most other QB rankings. Meanwhile, his contribution was crucial because the Vikings were very average.

After a rough start to the next season, Culpepper tore every ligament in his knee in a game against the Panthers. This was effectively a death sentence upon his career as a starting quarterback. It ended his tenure in Minnesota and he bounced from franchise to franchise before finally retiring. Ligament injuries were worse than many other health issues because they robbed players of mobility and pace and this one was more than career-threatening for Culpepper.