6. Oilers vs. Steelers (1980)
The only reason why this one doesn’t feature higher on this list is that replay wasn’t available at the time. However, it did cause an entire franchise to leave their city. Bud Adams was determined to remove the Oilers from Houston but this put the nail in their coffin. They met the Steelers in the AFC Championship game and suffered a devastating loss. Mike Renfro should have had a touchdown but the officials needlessly ruled it out (via SBNation).
Late in the fourth quarter, QB Dan Pastorini found Renfro before the receiver fell out of bounds. It was an amazing catch because he ensured both feet stayed in bounds before he fell out. Unfortunately, the referee didn’t see it that way because he ruled against Renfro. This was six years before the introduction of the NFL video replay system. In the end, it cost the Oilers a Super Bowl appearance and their identity.