25. Isaiah Wilson
There’s a strong argument that Wilson is a top-10 worst pick of all time. The Titans used their first-round selection on the former Georgia offensive tackle. It appeared to be a good move because he had fantastic physical attributes and performed well for the Bulldogs (via Sports Illustrated).
But he only made a single appearance for the Titans after a season of legal trouble. He went on a high-speed car chase and also violated NFL health policies. In the end, Tennessee had enough and cut ties with the player. He wasted his talent more than anybody else over the past few seasons.