Philadelphia Phillies (2011)
This was a harrowing heartbreaker for the Phillies because they had one of their greatest rosters. They witnessed slugger Ryan Howard tear his ACL and he was never the same player again. Meanwhile, the Cardinals beat Philadelphia by a single run after they exploded into life.
This was typical of a Phillies franchise with more meltdowns than a candle factory. Philadelphia won a franchise record 102 games that season but it meant nothing in the playoffs. They entered the postseason as World Series favorites but they couldn’t make it count (via The Athletic).