Andrew Luck
The Colts couldn’t believe their luck when Luck fell into their laps in 2012. This came after Peyton Manning missed the entire year because of neck surgery. They went 2-12 and finished with the worst record in the NFL. Meanwhile, Luck had decided to finish his degree at Stanford before entering the NFL Draft (via ESPN).

Suddenly, Indy had the perfect successor to their franchise icon. There’s no denying that Luck was a brilliant player and he made four Pro Bowl appearances. He also led the league in passing yards in 2014. But they wasted his amazing talent by failing to protect him and he shockingly retired right before the 2019 season at the tender age of 29.