11. Miami Dolphins vs New England Patriots (2018)
This remains one of the biggest upsets of the last decade because of the statistical improbability. The Dolphins played the Patriots in 2018 and rocked the entire NFL. New England was an 8.5-point favorite and led for most of the game. However, they never put Miami away and paid the price. “The Miracle in Miami” instantly became an iconic moment as Kenyan Drake scored the game-winning touchdown.

The multi-lateral touchdown was breathtaking but eminently avoidable. If the Patriots put the game to bed, it wouldn’t have happened. But Miami believed in themselves. Ryan Tannehill started the move and it ended with Drake’s 52-yard winning run. The final score was 33-32 (via Action Network). Miami was a +319 underdog at this point in the game. Nobody gave them a chance.