21. St. Louis Rams vs. New Orleans Saints (2011)
The Rams were pitiful in 2011. They carried a 0-6 record into this game against the Saints. But the double-digit underdogs sparked one of the biggest shocks of the last decade. St. Louis only won two games that season, however, they enjoyed this victory. Steven Jackson had a career game. He rushed for over 100 yards and two touchdowns.

Drew Brees extended his touchdown streak to 35 games but threw two key interceptions. It just goes to show that the stat line doesn’t always tell the full story. The Rams were a good value for their victory because they never stopped running. Steve Spagnuolo didn’t have a lot to celebrate during his tenure in Missouri (via St. Louis Post-Dispatch). But this was a great day for the defensive expert.