2. Jacksonville Jaguars vs. Buffalo Bills (2021)
There was no reason to believe that the Jaguars stood a chance against the Bills in this game. Urban Meyer’s short tenure in charge of Jacksonville was a turgid mess. He took a college football approach to the pro game and it was a disaster. Meanwhile, the Bills were bonafide AFC contenders. However, the Jaguars defied a 14.5 spread to upset the odds (via Tipico Sportsbook).
This game was a living nightmare for Bills QB Josh Allen. The Jaguars intercepted twice, sacked him four times, and forced a key fumble. Meanwhile, Jags outside linebacker Josh Allen had an amazing game. No, that isn’t a typo. The pair had the same name but vastly different fortunes. In the end, the Jaguars won 9-6 in one of the biggest upsets of the last decade. It was the sixth-biggest since 1990.