
17. Larry Holmes KO
Holmes had a legendary championship-winning career before he ever faced Tyson. After back-to-back losses to Michael Spinks, he retired but agreed to come back and fight ‘Iron Mike’ in a bid to win back the heavyweight title. What happened next was absolutely stunning.
Tyson dropped him with a jab-cross combination in the fourth round. Holmes got back to his feet but his younger opponent knocked him down again. He rose up and fought for another minute before Tyson landed a savage right hook, becoming the only man to knock Holmes out.