Appalachian State def. Michigan – 2007:
Here we could have the biggest upset in the history of NCAA football. The Michigan Wolverines were deservedly 27-point favorites when they welcomed FCS team Appalachian State to their revered Big House.
Although The Mountaineers would win the FCS national title that year, they were still predicted to get smoked by the Wolverines. That did not transpire. Appalachian State picked up a 34-32 win to shove everyone watching’s jaws to the ground.