New York Giants def. New England Patriots – Super Bowl XLII in 2008:
The 2007 version of the New England Patriots was the most dominant regular season team in NFL history. They destroyed every team on their way to a perfect 16-0 mark, with Tom Brady setting the NFL record for most touchdown passes in a single regular season.
The Patriots went into Super Bowl XLII as monstrous 12-point favorites over the opposing New York Giants. True, it took a lucky catch from wideout David Tyree where he held the ball against his helmet and a last-minute touchdown pass from Eli Manning to Plaxico Burress, but they shocked the entire world. Their defensive pressure of Brady was also an unsung reason why they could hold New England to only 14 total points. And like that, the Pats’ shot at perfection was sent down the drain.