Houston Oilers – 1992
This Oilers’ defeat may have been the death knell for the franchise in Texas. Everything went downhill from this moment and soon they were playing football in Nashville. Houston could only blame themselves as they threw away a 28-3 halftime lead. This should have been unassailable but the Bills didn’t give up (via History).

Bills Backup Frank Reich stayed calm and put his team through the motions. Somehow they took the lead but the Oilers dragged them into overtime. In the end, it was all for nothing as Buffalo kicked the winning field goal. This was a cruel defeat for the Oilers to take because they thought they were out of sight.