San Diego Chargers – 2006
The Chargers fired Marty Schottenheimer after this loss against the Patriots. He led the Chargers to a 14-2 regular season before they faced the Patriots in the Divisional Round. San Diego justifiably held the favorites tag against the 10-6 Pats. They had a better record and a stronger roster on paper (via Bleacher Report).

However, New England had a lot of postseason experience and three recent Super Bowl wins. Tom Brady didn’t play well either with three interceptions. But San Diego threw the game away after retrieving the ball. A shocking play cost their head coach his job after Marlon McCree lost the ball.