Week 1 2003
The first game of the 2003 season saw Brady post the worst display of his Patriots career. He never had a performance like this again in New England but this was terrible. He threw a career-high four interceptions and no touchdown passes in a blowout loss against the Bills (via CBS News).

This seriously embarrassed Brady because he sets high standards for himself and his teammates. However, most of the Patriots played horribly in this one as Buffalo won 31-0. In the end, this didn’t matter because it woke the Patriots up. They won Super Bowl XXXVIII against the Panthers.