21. Jake Delhomme
Delhomme’s Panthers met the Cardinals in the 2008 playoffs. Carolina was confident of beating Arizona because they already beat them in the regular season. Delhomme played a crucial role in that victory as he dissected the Cards. They were unable to stop him because his passing was on point. However, they produced an upset in the playoffs (via NBC Sports).
Meanwhile, Delhomme picked the worst possible time to be brutal as he threw pick after pick. Furthermore, he only produced a single touchdown pass in the game. This crushing defeat affected him for the rest of his career because he failed to deliver. Delhomme was their best quarterback but this hurt him.