Patriots 56 – Bills 10 (2007)
Everybody remembers 2007 as the year when the Patriots almost had a perfect season. They were at the peak of their powers in this dominant Week 11 victory. Tom Brady and Randy Moss combined to destroy Buffalo. It was a breathtaking display in one of the biggest beatdowns of the year (via ESPN).
Brady threw five touchdowns for the third time that season. Meanwhile, Moss caught four touchdowns as he proved to be too hot to handle. Ultimately, the Patriots fell short of the ultimate achievement as the Giants shocked them in the Super Bowl. But games like this one show why that shouldn’t have happened.