Saints 62 – Colts 7 (2011)
This is a day that Drew Brees remembers fondly because it was one of the best of his Saints career. He threw five touchdowns as he completed 31 of 35 passes for 325 yards. Meanwhile, New Orleans demolished the Colts as the latter threw in the towel (via ESPN).
Peyton Manning’s injury kept him out for the entire season. They tanked the year so that they could select Andrew Luck in the Draft. In the end, they had nothing to hurt the Saints who gleefully took advantage. Marques Colston and John Kasey did the early damage to finish this contest.