Chiefs 49 – Cardinals 0 (2002)
This shutout loss came out of nowhere because the Chiefs had the worst defense in the league. The Cardinals suffered the NFL’s most significant defeat since 1989 as they capitulated for their sixth-straight loss. Priest Holmes rushed for a pair of touchdowns and also 169 yards (via L.J. World).
It hurt Arizona’s players because they didn’t show up on the day. They couldn’t understand why they failed to put any points on the scoreboard against a horrific defense. Yes, they had plenty of injuries but that didn’t excuse their lack of heart and effort. This was one of the biggest NFL beatdowns we’ve ever seen.