Robert Griffin III
Griffin had an outstanding rookie season as he helped Washington to the playoffs and earned a Pro Bowl nomination. He threw for 3,200 yards with 20 touchdowns as everybody expected him to go from strength to strength. But then he tore knee ligaments in the Wild Card round against the Seahawks.
Later, the quarterback admitted that he shouldn’t have played in the game. His body was under severe stress and he suffered several injuries throughout the year. In the end, he played through the pain barrier but it cost him dearly. It ruined more than one game because his career never recovered (via Bleacher Report).