15. Mercer vs. Duke (2014)
Despite being such a prestigious program, Duke has endured some shocking upsets over the years. Two years after Lehigh humiliated them, the Blue Devils suffered another embarrassing defeat. This time it came at the hands of the Mercer Bears in the first round of the NCAA tournament.
Hilariously, North Carolina fans bought jerseys off the backs of the Mercer students (via Washington Post). They still wear them when they play Duke because it infuriates their rivals. Mercer put in a great team performance because they didn’t have an outstanding individual like some of the schools on this list.