11. George Mason vs. Connecticut (2006)
Most March Madness upsets happen in the opening rounds. But it’s rare that teams are able to repeat the same stunning results against the best teams. However, in 2006, George Mason belied their lowly status and made it all the way to the Elite Eight against the Huskies (via Yahoo).
The 11th-seeded school played without fear after beating the reigning champions, North Carolina. It was a close game but the Patriots squeaked past Connecticut by two points. They totally deserved their place in the Final Four after winning 86-84 thanks to their incredible story.