21. Lehigh vs. Duke (2012)
This wasn’t the strongest edition of the Blue Devils but make no mistake, they were still heavy favorites against Lehigh. The pair met in a major bracket-buster in the 2012 NCAA tournament. C.J. McCollum exploded into life and stunned Duke with a game-high 30 points (via NBC Sports).
In the end, Lehigh won the game 75-70 in one of the tournament’s biggest-ever upsets. They lost in the next round against Xavier, but nobody can take this result away from them (via NBC Sports). It was unlikely and unexpected. That’s everything fans love to see when a small fry takes on the big guns.