14. Purdue vs Ohio State (2018)
West Lafayette saw a thrilling and emotional encounter between Purdue and the Buckeyes. Coach Urban Meyer doesn’t lose very often but the Boilermakers inflicted pain upon him. They blew Ohio State out 49-20 in one of the most eye-catching upsets of the year (via SBNation).
Furthermore, Purdue had an emotional external motivation. They played their hearts out for Tyler Trent, a fellow student with terminal cancer. Despite this, it was still remarkable that they overcame the No. 2 team in the nation. However, it brought smiles to everybody’s faces.