
8. Northern Iowa vs. Kansas (2009)
Kansas suffered a shocking and humiliating loss in 2009. That’s because they became the first top overall seed to lose a first-round game. Northern Iowa became one of the all-time bracket busters when they shocked the Jayhawks. They just shouldn’t have pulled it off.

But somehow, they did. It was a back-and-forth clash of the titans with both teams leading at various points. The Panthers secured a narrow one-point lead with minutes left. But then they sealed the win with a glorious three-pointer. In the end, they made it to the Elite Eight (via Vegas Insider).