
6. Virginia Commonwealth vs. Kansas (2011)
Many people didn’t think that VCU should even have been in the tournament. Tournament bettors didn’t expect them to stick around for long. But they received a couple of great fixtures that saw them cruise into the Elite Eight. That’s where they faced the Jayhawks.

Most gamblers expected their run to end because Kansas had a much stronger team. However, VCU roared into an insurmountable lead. They led by 17 points before the Jayhawks even got on the scoreboard. The No. 1 seed didn’t know what was happening (via L.A. Times).