22. Harvard vs. Stanford (1998)
Statistically, this was one of the biggest NCAA shocks ever in men’s or women’s tournament history. It’s the only time that a No. 16 seed defeated a No. 1 seed in March Madness. This is why fans remember this game with a special fondness.
However, there are a couple of caveats. First, Stanford lost some key players to injury in the previous game. Meanwhile, Harvard had an elite star in their ranks in Allison Feaster. Nonetheless, this was still a shocker and worthy of its place on this list (via ESPN).