12. George Mason vs. Connecticut (2006)
George Mason was the name on everybody’s lips after their unlikely run to the Final Four. This included an improbable victory over Connecticut in Elite Eight. The Big East winners should have probably had too much for the N0. 11 seed.

After all, the Huskies are one of the strongest teams in the NCAA tournament. But George Mason had a series of inspired performances. After beating Michigan State they continued to show resolve. Finally, they defeated Connecticut to win the hearts of the nation (via Yardbreaker).