
20. Lehigh vs. Duke (2012)
2012 saw a pair of outrageous upsets. Nobody saw this bracket-buster coming because it was so outrageous. Duke was one of the strongest teams in the entire tournament. Later, it emerged that they had eight future NBA stars on their ridiculously-stacked roster.

In the end, it didn’t matter. That’s because Lehigh boasted a future NBA player of their own in C.J. McCollum. He lit up the game as he posted 30 points in a glorious victory. This one stunned gamblers across the United States because there was no reason to expect it (via CBS Sports).